Sifting through countless of stocks in the Health Care Equipment & Supplies industry can be tedious, and sometimes two stocks are just too similar to judge which is the better investment. If you’re on the fence about investing in Align Technology, Inc. or Repligen Corporation because you’re not sure how they measure up, it’s important to compare them on a few factors before making your decision.

Read on to learn how Align Technology, Inc. and Repligen Corporation compare based on key financial metrics to determine which better meets your investment needs.

About Align Technology, Inc. and Repligen Corporation

Align Technology, Inc. provides Invisalign clear aligners, Vivera retainers, and iTero intraoral scanners and services in the United States, Switzerland, and internationally. The company’s Clear Aligner segment offers Invisalign comprehensive package to treat adults and teens malocclusion and features, and orthodontic needs of teenage or younger patients; and Invisalign First Phase I and Invisalign First Comprehensive Phase 2 package for younger patients between the ages of six and ten years with a mixture of primary/baby and permanent teeth. This segment also provides Invisalign express, Invisalign lite, and Invisalign moderate; Invisalign Go, Invisalign Go express, and Invisalign Go Plus; retention products, Invisalign training, adjusting tools used by dental professionals during treatment, ancillary Invisalign accessory products, and other oral health products; Invisalign Professional Whitening system; Invisalign Palatal Expander, a 3D printed orthodontic device; and 3D printing solutions. Its Imaging Systems and CAD/CAM Services segment offers iTero intraoral scanning system, a single hardware platform for restorative or orthodontic procedures; exocad, a computer-aided design and computer-aided manufacturing software; orthodontist software for digital records storage, orthodontic diagnosis, and fabrication of printed models and retainers; and restorative software for general practitioner dentists, prosthodontists, periodontists, and oral surgeons. This segment also offers Invisalign outcome simulator, a chair-side and cloud-based application for the iTero scanner; Invisalign progress assessment tool; Align Oral Health Suite, a digital interface for dental consultations; iTero TimeLapse technology for doctors or practitioners to compare a patient’s historic 3D scans to the present-day scan; and subscription software, disposables, rents scanners, and pay per scan services. Align Technology, Inc. was incorporated in 1997 and is headquartered in Tempe, Arizona.

Repligen Corporation, a life sciences company, develops and commercializes bioprocessing technologies and systems in North America, Europe, the Asia Pacific, and internationally. The company’s products include hollow fiber consumables, KRM chromatography system, resins for new modalities, PATsmart MAVERICK and PATsmart MAVEN for real-time monitoring and control of critical bioprocess parameters, PATsmart REBEL, an at-line cell culture media analyzer; and PATsmart ZipChip, a high-resolution sample separations device, PATsmart SoloVPE slope spectroscopy system, and SoloVPE PLUS System. It offers Protien A ligands that are the binding components of Protein A affinity chromatography resins; and cell culture growth factor products. The company also provides chromatography products, including OPUS pre-packed chromatography columns, which are used in the purification and quality control of biological drugs, as well as ELISA test kits. In addition, it offers filtration products, such as XCell ATF Cell Retention Systems that are filtration devices used in upstream perfusion and cell culture processing; TangenX flat sheet cassettes, which are used in downstream biologic drug concentration, buffer exchange, and formulation processes; KrosFlo tangential flow filtration and tangential flow depth filtration systems; and ProConnex TFDF flow paths. Further, it provides process analytics products, such as slope spectroscopy systems. The company offers its products under the OPUS, XCell, XCell ATF, TFDF, KrosFlo, SIUS, ProConnex, Spectra/Por, NGL-Impact, SoloVPE, FlowVPE, RPM, XO, Metenova MixOne, and AVIPure and FlowVPX brands. The company sells its products to life sciences, biopharmaceutical, and diagnostics companies; laboratory researchers; and contract manufacturing organizations. Repligen Corporation has a collaboration agreement with Navigo Proteins GmbH to develop multiple affinity ligands. The company was incorporated in 1981 and is headquartered in Waltham, Massachusetts.

Latest Health Care Equipment & Supplies and Align Technology, Inc., Repligen Corporation Stock News

As of August 7, 2026, Align Technology, Inc. had a $12.3 billion market capitalization, compared to the Health Care Equipment & Supplies median of $377.3 million. Align Technology, Inc.’s stock is up 11.2% in 2026, up 2.7% in the previous five trading days and up 26.85% in the past year.

Currently, Align Technology, Inc.’s price-earnings ratio is 30.2. Align Technology, Inc.’s trailing 12-month revenue is $4.1 billion with a 10.0% net profit margin. Year-over-year quarterly sales growth most recently was 4.3%. Analysts expect adjusted earnings to reach $11.292 per share for the current fiscal year. Align Technology, Inc. does not currently pay a dividend.

As of August 7, 2026, Repligen Corporation had a $9.3 billion market cap, putting it in the 76th percentile of all stocks. Repligen Corporation’s stock is NA 0% in 2026, up 16.2% in the previous five trading days and up 46.24% in the past year.

Currently, Repligen Corporation’s price-earnings ratio is 224.6. Repligen Corporation’s trailing 12-month revenue is $785.1 million with a 5.3% net profit margin. Year-over-year quarterly sales growth most recently was 11.9%. Analysts expect adjusted earnings to reach $2.064 per share for the current fiscal year. Repligen Corporation does not currently pay a dividend.

How We Compare Align Technology, Inc. and Repligen Corporation Stock Grades

Stock evaluation requires access to huge amounts of data and the knowledge and time to sift through it all, make sense of financial ratios, read income statements and analyze recent stock movements. AAII created A+ Investor, a robust data suite that condenses data research in an actionable and customizable way suitable for investors of all knowledge levels, to help investors streamline and work through such data.

AAII’s proprietary stock grades come with A+ Investor. These offer intuitive A‐F grades for each of five key investing factors: value, growth, momentum, earnings estimate revisions and quality. Here, we’ll take a closer look at Align Technology, Inc. and Repligen Corporation’s stock grades to see how they measure up against one another.

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Align Technology, Inc. and Repligen Corporation Stock Value Grades

Company	Ticker	Value
Align Technology, Inc.	ALGN	D
Repligen Corporation	RGEN	F

Successful stock investing involves buying low and selling high, so stock valuation is an important consideration for stock selection.

Buying stocks that are going to go up typically means buying stocks that are undervalued in the first place, although momentum investors may argue that point.

AAII’s A+ Investor Value Grade derives from a stock’s value score. The Value Score is the percentile rank of the average of the percentile ranks of the price-to-sales ratio, price-earnings ratio, enterprise-value-to-EBITDA (EV/EBITDA) ratio, shareholder yield, price-to-book-value ratio and price-to-free-cash-flow ratio. The score is variable, meaning it can consider all six ratios or, should any of the six ratios not be valid, the remaining ratios that are valid. To be assigned a Value Score, stocks must have a valid (non-null) ratio and corresponding ranking for at least two of the six valuation ratios.

Stocks with a Value Score from 81 to 100 are considered deep value, those with a score between 61 and 80 are a good value and so on.

Align Technology, Inc. has a Value Score of 37, which is Expensive. Repligen Corporation has a Value Score of 6, which is Ultra Expensive.

The Value Stock Winner: No Clear Winner

Neither Align Technology, Inc. or Repligen Corporation has a high enough value grade to be considered a “winner.” Investors who are considering these companies should do additional due diligence and research to see if either could be a good addition to their portfolio. It’s important to look at a wide range of financial metrics in order to determine if Align Technology, Inc. or Repligen Corporation is the better investment when it comes to value.

Align Technology, Inc. and Repligen Corporation’s Momentum Grades

Company	Ticker	Momentum
Align Technology, Inc.	ALGN	C
Repligen Corporation	RGEN	A

Momentum grades help to uncover stocks experiencing anomalously high rates of return; research finds that stocks with high relative levels of momentum tend to outperform, whereas those with low levels of momentum tend to continue underperforming. Momentum is based on the price change of a stock over a specified period relative to all other stocks.

Typically, AAII looks at the weighted relative strength over the trailing four quarters. The weighted four-quarter relative strength rank is the relative price change for each of the past four quarters. The most recent quarterly price change is given a weight of 40% and each of the three previous quarters are given a weighting of 20%.

Align Technology, Inc. has a Momentum Score of 58, which is Average. Repligen Corporation has a Momentum Score of 82, which is Very Strong.

The Momentum Grade Winner: Repligen Corporation

As you can clearly see from the Momentum Grade breakdown above, Repligen Corporation is considered to have stronger momentum compared to Align Technology, Inc.. For those specifically looking for companies that have stronger momentum compared to other companies in the same industry, Repligen Corporation could be a good stock to invest in. However, it’s important for investors to analyze multiple factors based on a wide range of metrics before deciding whether to buy.

Align Technology, Inc. and Repligen Corporation’s Estimate Revisions Grades

Company	Ticker	Earnings Estimate
Align Technology, Inc.	ALGN	C
Repligen Corporation	RGEN	B

Earnings estimate revisions scores consider the magnitude of a company’s earnings surprise in its last two reported fiscal quarters. Often, positive surprises beget further positive surprises‐or at least continued sales growth (the exact opposite is generally true, too).

Estimate revisions offer an indication of what analysts are thinking about the short-term prospects of a firm. Estimate revisions are based on the statistical significance of a firm’s last two quarterly earnings surprises and the percentage change in its consensus estimate for the current fiscal year over the past month and past three months.

Align Technology, Inc. has a Earnings Estimate Score of 45, which is Neutral. Repligen Corporation has a Earnings Estimate Score of 76, which is Positive.

The Earnings Estimate Revisions Grade Winner: Repligen Corporation

As you can clearly see from the Earnings Estimate Revisions Grade breakdown above, Repligen Corporation has a better Earnings Estimate Revisions Grade than Align Technology, Inc.. For those who are specifically looking for companies with better short-term prospects when compared to other companies in the same industry, Repligen Corporation could be a good stock to invest in. However, it’s important to analyze multiple factors based on a wide range of metrics before deciding whether to buy.

Other Align Technology, Inc. and Repligen Corporation Grades

In addition to Estimate Revisions, Momentum and Value, A+ Investor also provides grades for Growth and Quality.

Growth investing builds on the idea that stocks of companies exhibiting strong, consistent and prolonged growth outperform those of slower-growth companies. AAII measures growth through consistency of annual sales growth, five-year sales growth rankings adjusted for extreme levels, and consistency of positive annual cash from operations.

AAII’s A+ Investor Quality Grade comes from the ranking of key metrics. Specifically, the quality grade is the percentile rank of the composite of return on assets (ROA), return on invested capital (ROIC), gross profit relative to assets, buyback yield, change in total liabilities to assets, accruals, Z double prime bankruptcy risk (Z) score and F-Score.

These 2 key factors, when combined with the above, provide a holistic view into a particular stock. Further, by joining A+ Investor you can see whether Align Technology, Inc. and Repligen Corporation pass any of our 60+ stock screens that have outperformed the market since their creation.

So, Which Is the Better Investment, Align Technology, Inc. or Repligen Corporation Stock?

Overall, Align Technology, Inc. stock has a Value Score of 37, Momentum Score of 58 and Estimate Revisions Score of 45.

Repligen Corporation stock has a Value Score of 6, Momentum Score of 82 and Estimate Revisions Score of 76.

Comparing Align Technology, Inc. and Repligen Corporation’s grades, scores and metrics can act as a solid basis to determine whether they may be a good investment or not. You’ll also want to look at your portfolio’s asset allocation as well as your risk tolerance and financial goals to see if either of these stocks would make a good fit for you. AAII can help you figure out which investments align with your individual needs and preferences.

Investors are encouraged to do their own due diligence and research. In this way, individuals can effectively become managers of their own assets‐without having to rely on others for financial independence. You can count on AAII for timeless articles on financial planning and stock-picking, unbiased research and actionable analysis.

A+ Investor adds to our qualitative teaching with a powerful data suite to help you whittle down investment choices to find stocks, exchange-traded funds (ETFs) or mutual funds that meet your needs.

AAII Disclaimer

We make no representations or warranties that any investor will, or is likely to, achieve profits similar to those shown, because past, hypothetical or simulated performance is not necessarily indicative of future results. Before making an investment decision, you should consider your circumstances and whether the information on our content is applicable to your situation. This information was prepared in good faith, and we accept no liability for any errors or omissions. The full disclaimer can be read here.