Sifting through countless of stocks in the Health Care Equipment & Supplies industry can be tedious, and sometimes two stocks are just too similar to judge which is the better investment. If you’re on the fence about investing in Axogen, Inc., Align Technology or Inc. because you’re not sure how they measure up, it’s important to compare them on a few factors before making your decision.

Read on to learn how Axogen, Inc., Align Technology and Inc. compare based on key financial metrics to determine which better meets your investment needs.

About Axogen, Inc., Align Technology and Inc.

Axogen, Inc., together with its subsidiaries, engages in the development and commercialization of the technologies used for peripheral nerve regeneration and repair worldwide. The company offers Avance Nerve Graft, a processed nerve allograft intended for the surgical repair of peripheral nerve discontinuities; Axoguard Nerve Connector, a coaptation aid used to align and connect severed peripheral nerve ends in a tensionless repair; and Axoguard Nerve Protector, a product used to protect and wrap damaged peripheral nerves and reinforce reconstructed nerve gaps. It also provides Axoguard HA+ Nerve Protector, a surgical implant for non-constricting protection of the peripheral nerves; Axoguard Nerve Cap, a porcine submucosa ECM product; Avive+ Soft Tissue Matrix, a multi-layer amniotic membrane allograft; and Avance Method, a technique to process Avance Nerve Graft from donated human peripheral nerve tissue. In addition, the company offers peripheral nerve tissue recovery and acquisition, and testing, as well as donor medical review and release, debridement and other processing steps, packaging, and sterilization. It provides its products to hospitals, surgery centers and military hospitals, calling on surgeons, including plastic reconstructive surgeons, orthopedic and plastic hand surgeons, and certain oral and maxillofacial surgeons through independent in-country distributors. The company is headquartered in Alachua, Florida.

Align Technology, Inc. provides Invisalign clear aligners, Vivera retainers, and iTero intraoral scanners and services in the United States, Switzerland, and internationally. The company’s Clear Aligner segment offers Invisalign comprehensive package to treat adults and teens malocclusion and features, and orthodontic needs of teenage or younger patients; and Invisalign First Phase I and Invisalign First Comprehensive Phase 2 package for younger patients between the ages of six and ten years with a mixture of primary/baby and permanent teeth. This segment also provides Invisalign express, Invisalign lite, and Invisalign moderate; Invisalign Go, Invisalign Go express, and Invisalign Go Plus; retention products, Invisalign training, adjusting tools used by dental professionals during treatment, ancillary Invisalign accessory products, and other oral health products; Invisalign Professional Whitening system; Invisalign Palatal Expander, a 3D printed orthodontic device; and 3D printing solutions. Its Imaging Systems and CAD/CAM Services segment offers iTero intraoral scanning system, a single hardware platform for restorative or orthodontic procedures; exocad, a computer-aided design and computer-aided manufacturing software; orthodontist software for digital records storage, orthodontic diagnosis, and fabrication of printed models and retainers; and restorative software for general practitioner dentists, prosthodontists, periodontists, and oral surgeons. This segment also offers Invisalign outcome simulator, a chair-side and cloud-based application for the iTero scanner; Invisalign progress assessment tool; Align Oral Health Suite, a digital interface for dental consultations; iTero TimeLapse technology for doctors or practitioners to compare a patient’s historic 3D scans to the present-day scan; and subscription software, disposables, rents scanners, and pay per scan services. Align Technology, Inc. was incorporated in 1997 and is headquartered in Tempe, Arizona.

Latest Health Care Equipment & Supplies and Axogen, Inc., Align Technology, Inc. Stock News

As of October 5, 2026, Axogen, Inc. had a $2.2 billion market capitalization, compared to the Health Care Equipment & Supplies median of $408.1 million. Axogen, Inc.’s stock is up 12.5% in 2026, down 13.2% in the previous five trading days and up 108.17% in the past year.

Currently, Axogen, Inc. does not have a price-earnings ratio. Axogen, Inc.’s trailing 12-month revenue is $251.2 million with a -13.4% net profit margin. Year-over-year quarterly sales growth most recently was 22.9%. Analysts expect adjusted earnings to reach $0.470 per share for the current fiscal year. Axogen, Inc. does not currently pay a dividend.

As of October 5, 2026, Align Technology, Inc. had a $10.0 billion market cap, putting it in the 78th percentile of all stocks. Align Technology, Inc.’s stock is down 8.7% in 2026, down 1% in the previous five trading days and up 9.29% in the past year.

Currently, Align Technology, Inc.’s price-earnings ratio is 24.4. Align Technology, Inc.’s trailing 12-month revenue is $4.1 billion with a 10.0% net profit margin. Year-over-year quarterly sales growth most recently was 4.3%. Analysts expect adjusted earnings to reach $11.270 per share for the current fiscal year. Align Technology, Inc. does not currently pay a dividend.

How We Compare Axogen, Inc., Align Technology and Inc. Stock Grades

Stock evaluation requires access to huge amounts of data and the knowledge and time to sift through it all, make sense of financial ratios, read income statements and analyze recent stock movements. AAII created A+ Investor, a robust data suite that condenses data research in an actionable and customizable way suitable for investors of all knowledge levels, to help investors streamline and work through such data.

AAII’s proprietary stock grades come with A+ Investor. These offer intuitive A‐F grades for each of five key investing factors: value, growth, momentum, earnings estimate revisions and quality. Here, we’ll take a closer look at Axogen, Inc., Align Technology and Inc.’s stock grades to see how they measure up against one another.

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Axogen, Inc., Align Technology and Inc. Growth Grades

Company	Ticker	Growth
Axogen, Inc.	AXGN	C
Align Technology, Inc.	ALGN	A

The foundation of growth investing is seeking out stocks of companies exhibiting strong, consistent and prolonged growth that is expected to continue into the future.

In order to compute the growth score and assign it a letter grade, the percentile ranks for each of three components‐consistency of annual sales growth, five-year sales growth rankings adjusted for extreme levels, and consistency of positive annual cash from operations‐must be determined. These three rank figures are added together, and the sum is ranked against the entire stock universe to arrive at a company’s Growth Score to create an equal distribution of grades.

The companies in the bottom 20% of the stock universe receive Growth Grades of F, considered to be very weak, while those in the top 20% receive A grades, which are considered very strong.

Axogen, Inc. has a Growth Score of 49, which is Average. Align Technology, Inc. has a Growth Score of 95, which is Very Strong.

The Growth Grade Winner: Align Technology, Inc.

As you can clearly see from the Growth Grade breakdown above, Align Technology, Inc. has a more attractive growth grade than Axogen, Inc.. For investors who focus solely on how a company is growing relative to other companies in the same industry, Align Technology, Inc. could be a good stock to add to their portfolio. However, it’s important for investors to analyze multiple factors based on a wide range of metrics before deciding whether to buy.

Axogen, Inc., Align Technology and Inc.’s Quality Grades

Company	Ticker	Quality
Axogen, Inc.	AXGN	B
Align Technology, Inc.	ALGN	A

Like the Value Grade, AAII’s A+ Investor Quality Grade comes from the percentile rank of key metrics. Specifically, the Quality Score is the percentile rank of the average of the percentile ranks of return on assets (ROA), return on invested capital (ROIC), gross profit relative to assets, buyback yield, change in total liabilities to assets, accruals, Z double prime bankruptcy risk (Z) score and the F-Score.

The score is variable, meaning it can consider all eight measures or, should any of the eight measures not be valid, the remaining measures that are valid. To be assigned a Quality Score, stocks must have a valid (non-null) measure and corresponding ranking for at least four of the eight quality measures.

The Quality Score is used to assess the underlying “quality” of a particular stock. A higher-quality stock possesses traits associated with upside potential and reduced downside risk. Backtesting of the Quality Grade shows that stocks with higher grades, on average, outperformed stocks with lower grades over the period of 1998 through 2019.

Stocks receive better grades (higher scores) for having higher scores for the quality subcomponents and worse grades (lower scores) for lower scores for the subcomponents.

Axogen, Inc. has a Quality Score of 80, which is Strong. Align Technology, Inc. has a Quality Score of 98, which is Very Strong.

The Quality Grade Winner: Align Technology, Inc.

As you can clearly see from the Quality Grade breakdown above, Align Technology, Inc. has a better overall quality grade than Axogen, Inc.. For investors who are looking for companies with higher quality than others in the same industry, Align Technology, Inc. could be a good stock to add to their portfolios. However, it’s important for investors to analyze multiple factors based on a wide range of metrics before deciding whether to buy.

Axogen, Inc., Align Technology and Inc.’s Estimate Revisions Grades

Company	Ticker	Earnings Estimate
Axogen, Inc.	AXGN	C
Align Technology, Inc.	ALGN	C

Earnings estimate revisions scores consider the magnitude of a company’s earnings surprise in its last two reported fiscal quarters. Often, positive surprises beget further positive surprises‐or at least continued sales growth (the exact opposite is generally true, too).

Estimate revisions offer an indication of what analysts are thinking about the short-term prospects of a firm. Estimate revisions are based on the statistical significance of a firm’s last two quarterly earnings surprises and the percentage change in its consensus estimate for the current fiscal year over the past month and past three months.

Axogen, Inc. has a Earnings Estimate Score of 43, which is Neutral. Align Technology, Inc. has a Earnings Estimate Score of 43, which is Neutral.

The Earnings Estimate Revisions Stock Winner: No Clear Winner

Neither Axogen, Inc., Align Technology or Inc. has an Earnings Estimate Revisions Grade that could be considered a “winner.” Investors considering these companies should do additional due diligence and research to see if either could be a good addition to their portfolios. It’s important to look at a wide range of financial metrics in order to determine if Axogen, Inc., Align Technology or Inc. is the better investment when it comes to estimate revisions.

Other Axogen, Inc., Align Technology and Inc. Grades

In addition to Estimate Revisions, Growth and Quality, A+ Investor also provides grades for Value and Momentum.

Momentum grades help uncover stocks experiencing anomalously high rates of return; research finds that stocks with high relative levels of momentum tend to outperform, whereas those with low levels of momentum tend to continue underperforming.

Successful stock investing involves buying low and selling high, so stock valuation is an important consideration for stock selection. Buying stocks that are going to go up typically means buying stocks that are undervalued in the first place, although momentum investors may argue that point.

These 2 key factors, when combined with the above, provide a holistic view into a particular stock. Further, by joining A+ Investor you can see whether Axogen, Inc., Align Technology and Inc. pass any of our 60+ stock screens that have outperformed the market since their creation.

So, Which Is the Better Investment, Axogen, Inc., Align Technology or Inc. Stock?

Overall, Axogen, Inc. stock has a Growth Score of 49, Estimate Revisions Score of 43 and Quality Score of 80.

Align Technology, Inc. stock has a Growth Score of 95, Estimate Revisions Score of 43 and Quality Score of 98.

Comparing Axogen, Inc., Align Technology and Inc.’s grades, scores and metrics can act as a solid basis to determine whether they may be a good investment or not. You’ll also want to look at your portfolio’s asset allocation as well as your risk tolerance and financial goals to see if either of these stocks would make a good fit for you. AAII can help you figure out which investments align with your individual needs and preferences.

Investors are encouraged to do their own due diligence and research. In this way, individuals can effectively become managers of their own assets‐without having to rely on others for financial independence. You can count on AAII for timeless articles on financial planning and stock-picking, unbiased research and actionable analysis.

A+ Investor adds to our qualitative teaching with a powerful data suite to help you whittle down investment choices to find stocks, exchange-traded funds (ETFs) or mutual funds that meet your needs.

AAII Disclaimer

We make no representations or warranties that any investor will, or is likely to, achieve profits similar to those shown, because past, hypothetical or simulated performance is not necessarily indicative of future results. Before making an investment decision, you should consider your circumstances and whether the information on our content is applicable to your situation. This information was prepared in good faith, and we accept no liability for any errors or omissions. The full disclaimer can be read here.