Stock Evaluator: Denali Therapeutics Inc. (DNLI)

Denali Therapeutics Inc. DNLI

$23.02 -1.33 -5.46%
July 31, 2026 4:00:00 PM EST November 10, 2021 Volume: 1,232,142
After Hours: $120.37   0.15  |  0.12% November 10, 2021 7:59 PM EST Volume: 72,713
USD NASD | DELAYED PRICE
SECTOR INDUSTRY
Health Care Biotechnology

A+ Stock Grade Summary:

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COMPANY SUMMARY
Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement therapy program for MPS II (Hunter Syndrome). Its Enzyme TransportVehicle (TV) programs include DNL952 for the treatment of Pompe disease; DNL111 for Parkinson’s and Gaucher diseases; and DNL622 for Hurler syndrome (MPS I). The company’s OTV programs also comprise DNL628 targeting tau for Alzheimer’s disease; and DNL422 targeting alpha synuclein for Parkinson’s disease, as well as antibody TV program includes DNL921 targeting Abeta for treating Alzheimer’s disease. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.

Commentary & Analysis


Financial Summary

Share Statistics DNLI Industry
Median
Percentile
(All Stocks)
Market Cap (Mil) $3,653.5 $252.6 62%
Shares Out (Mil) 186.6 52.3 75%
Institutional Ownership 95.6% 92.1% 68%
Float (Mil) 151.4 40.2 69%
Beta 1.00 0.95 60%
Avg Daily Volume (000s) 1,353 455 76%
Price Change
(52-week)
68.4% 52.9% 86%
Growth DNLI Industry
Median
Percentile
(All Stocks)
Sales (5yr) na 13.6% na
Net Income (5yr) (55.9%) (9.9%) 6%
EPS (5yr) (46.3%) 16.0% 4
Dividends (5yr) na 0.0% na
Cash Flow (5yr) (46.0%) (15.6%) 8%
Estimates Qtrly Current
Fiscal
Year
Next
Fiscal
Year
# of Estimates 15 15 16
Current EPS ($0.467) ($2.372) ($2.533)
Month Ago EPS ($0.533) ($2.315) ($2.478)
# Rev Up 1 0 0
# Rev Down 1 1 1
Three Months Ago EPS ($0.380) ($2.550) ($2.583)
Year/Year Chg (32.1%) (20.1%) (41.8%)
Financials DNLI Industry
Median
Percentile
(All Stocks)
Sales (TTM) (Mil) na $38 na
Net Income (TTM) (Mil) ($508) ($43) 3%
EPS (TTM) ($2.878) ($1.600) 12%
Operating Cash Flow (TTM) (Mil) ($412) ($31) 2%
Net Cash Flow (TTM) (Mil) $331 $5 88%
Long-Term Debt (Q1) (Mil) $30 $5 35%
Enterprise Value (Q1) (Mil) $2,077 $180 50%
Valuation DNLI Industry
Median
Percentile
(All Stocks)
P/B 3.94 2.56 73%
P/E na 19.0 na
Dividend Yield na 0.0% na
PEG (5yr hist) na 0.9 na
Ratios DNLI Industry
Median
Percentile
(All Stocks)
Gross Margin na 63.8% na
Net Margin na (67.3%) na
ROA (40.0%) (49.8%) 14%
ROE (49.6%) (55.5%) 15%
Liabilities to Assets 26.8% 30.3% 18%
F-Score 2 3 7%

Denali Therapeutics Inc. did not pass any screens on 7/31/2026.

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