Avoid the stress of overpaying for a stock or missing an opportunity by using the right tools and insights to evaluate Annexon, Inc. before investing.

In this article, we go over a few key elements for understanding Annexon, Inc.’s stock price such as:

• Annexon, Inc.’s current stock price and volume
• Why Annexon, Inc.’s stock price changed recently
• Upgrades and downgrades for ANNX from analysts
• ANNX’s stock price momentum as measured by its relative strength

About Annexon, Inc. (ANNX)

Before we jump into Annexon, Inc.’s stock price, history, target price and what caused it to recently rise, let’s take a look at some background.

Annexon, Inc., a clinical-stage biopharmaceutical company, discovers and develops medicines for treating inflammatory-related diseases. The company’s lead candidate is ANX005, an investigational full-length monoclonal antibody, which is in Phase 3 clinical trial for the treatment of patients with guillain-barré syndrome; completed Phase II clinical trial for treating Huntington’s disease; and in Phase 2a clinical trial for the treatment of amyotrophic lateral sclerosis. The company is also developing ANX007, an antigen-binding fragment (Fab) that is in Phase 3 program for the treatment of patients with geographic atrophy; and ANX1502, a novel oral small molecule inhibitor, which is in Phase 1 clinical trials for autoimmune indications. In addition, it develops ANX009, a C1q-blocking Fab that is in Phase I clinical trial for treating patients with lupus nephritis. The company was incorporated in 2011 and is headquartered in Brisbane, California.

Want to learn more about Annexon, Inc.’s stock? Click the button below to subscribe to A+ Investor and get access to everything you need to know about Annexon, Inc..

Annexon, Inc.’s Stock Price as of Market Close

As of December 12, 2025, 1:46 PM, CST, Annexon, Inc.’s stock price was $5.080.

Annexon, Inc. is up 0.79% from its previous closing price of $5.040.

During the last market session, Annexon, Inc.’s stock traded between $4.990 and $5.340. Currently, there are approximately 149.12 million shares outstanding for Annexon, Inc..

Annexon, Inc.’s trailing earnings per share are negative, so the stock does not have a meaningful P/E ratio. We suggest investors evaluate other financial metrics to understand its overall valuation.

Annexon, Inc. Stock Price History

Annexon, Inc.’s (ANNX) price is currently up 12.89% so far this month.

During the month of December, Annexon, Inc.’s stock price has reached a high of $5.340 and a low of $4.010.

Over the last year, Annexon, Inc. has hit prices as high as $5.660 and as low as $1.285. Year to date, Annexon, Inc.’s stock is down 0.97%.

Sign Up to Receive a Free Special Report Showing How A+ Grades Can Help You Make Smarter Investment Decisions

What Caused Annexon, Inc. Stock’s Price to Rise?

Stock prices are primarily based on seller supply and buyer demand. But have you ever wondered about what other factors affect a stock's price?

When an analyst changes their opinion of a stock by upgrading or downgrading their rating, it often leads to a sudden stock price adjustment. As of December 11, 2025, there were 2 analysts who downgraded Annexon, Inc.’s stock and 2 analysts who upgraded over the last month.

Additionally, you'll want to evaluate Annexon, Inc.’s financial health and valuation. Investors can use AAII's Value Grade, which combines six key valuation metrics like P/E and P/S ratios for a comprehensive analysis to conduct analysis on Annexon, Inc.’s valuation and financial health. This approach mitigates the limitations of single-metric evaluations.

Learn how to evaluate stocks with AAII Grades and Scores with A+ Investor today.

Lastly, news and media coverage as well as recent press reports about the company or its industry may cause stock prices to fluctuate. You can check out the most recent news articles about Annexon, Inc. (ANNX) by visiting AAII Stock Evaluator.

Relative Price Strength of Annexon, Inc.

Relative price strength measures a stock's performance against the market, helping investors identify stocks that are outperforming benchmarks.

For AAII’s Momentum Grade, a weighted relative price strength is calculated. Follow this link to learn more about the Momentum Grade.

As of December 11, 2025, Annexon, Inc. has a weighted four-quarter relative price strength of 25.20%, which translates to a Momentum Score of 93 and is considered to be Very Strong.

Want to learn more about how Annexon, Inc. is graded based on AAII’s composite scores for value, growth, quality and earnings estimate revisions? Subscribe to A+ Investor today.

Annexon, Inc. Stock Price: Bottom Line

As of December 12, 2025, Annexon, Inc.’s stock price is $5.080, which is up 0.79% from its previous closing price.

AAII advises against making stock decisions based solely on price or past returns. Instead, consider a variety of metrics, fundamentals, and analytics to evaluate a stock like Annexon, Inc. stock prices are influenced by market supply and demand and offer just a snapshot of a company's overall health.

Subscribing to AAII's A+ Investor provides access to comprehensive analytics and insights for confident investing.