Avoid the stress of overpaying for a stock or missing an opportunity by using the right tools and insights to evaluate Septerna, Inc. before investing.

In this article, we go over a few key elements for understanding Septerna, Inc.’s stock price such as:

• Septerna, Inc.’s current stock price and volume
• Why Septerna, Inc.’s stock price changed recently
• Upgrades and downgrades for SEPN from analysts
• SEPN’s stock price momentum as measured by its relative strength

About Septerna, Inc. (SEPN)

Before we jump into Septerna, Inc.’s stock price, history, target price and what caused it to recently rise, let’s take a look at some background.

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

Want to learn more about Septerna, Inc.’s stock? Click the button below to subscribe to A+ Investor and get access to everything you need to know about Septerna, Inc..

Septerna, Inc.’s Stock Price as of Market Close

As of May 08, 2026, 10:32 AM, CST, Septerna, Inc.’s stock price was $24.290.

Septerna, Inc. is up 1.29% from its previous closing price of $23.980.

During the last market session, Septerna, Inc.’s stock traded between $23.950 and $24.520. Currently, there are approximately 44.58 million shares outstanding for Septerna, Inc..

Septerna, Inc.’s trailing earnings per share are negative, so the stock does not have a meaningful P/E ratio. We suggest investors evaluate other financial metrics to understand its overall valuation.

Septerna, Inc. Stock Price History

Septerna, Inc.’s (SEPN) price is currently up 2.23% so far this month.

During the month of May, Septerna, Inc.’s stock price has reached a high of $25.250 and a low of $23.150.

Over the last year, Septerna, Inc. has hit prices as high as $32.630 and as low as $6.440. Year to date, Septerna, Inc.’s stock is down 12.88%.

Sign Up to Receive a Free Special Report Showing How A+ Grades Can Help You Make Smarter Investment Decisions

What Caused Septerna, Inc. Stock’s Price to Rise?

Stock prices are primarily based on seller supply and buyer demand. But have you ever wondered about what other factors affect a stock's price?

When an analyst changes their opinion of a stock by upgrading or downgrading their rating, it often leads to a sudden stock price adjustment. As of May 07, 2026, there were 0 analysts who downgraded Septerna, Inc.’s stock and 1 analyst who upgraded over the last month.

Additionally, you'll want to evaluate Septerna, Inc.’s financial health and valuation. Investors can use AAII's Value Grade, which combines six key valuation metrics like P/E and P/S ratios for a comprehensive analysis to conduct analysis on Septerna, Inc.’s valuation and financial health. This approach mitigates the limitations of single-metric evaluations.

Septerna, Inc.’s current valuation based on AAII’s Value Grade is a D, which means it is considered to be Expensive.

Learn how to evaluate stocks with AAII Grades and Scores with A+ Investor today.

Lastly, news and media coverage as well as recent press reports about the company or its industry may cause stock prices to fluctuate. You can check out the most recent news articles about Septerna, Inc. (SEPN) by visiting AAII Stock Evaluator.

Relative Price Strength of Septerna, Inc.

Relative price strength measures a stock's performance against the market, helping investors identify stocks that are outperforming benchmarks.

For AAII’s Momentum Grade, a weighted relative price strength is calculated. Follow this link to learn more about the Momentum Grade.

As of May 07, 2026, Septerna, Inc. has a weighted four-quarter relative price strength of 21.67%, which translates to a Momentum Score of 91 and is considered to be Very Strong.

Want to learn more about how Septerna, Inc. is graded based on AAII’s composite scores for value, growth, quality and earnings estimate revisions? Subscribe to A+ Investor today.

Septerna, Inc. Stock Price: Bottom Line

As of May 8, 2026, Septerna, Inc.’s stock price is $24.290, which is up 1.29% from its previous closing price.

AAII advises against making stock decisions based solely on price or past returns. Instead, consider a variety of metrics, fundamentals, and analytics to evaluate a stock like Septerna, Inc. stock prices are influenced by market supply and demand and offer just a snapshot of a company's overall health.

Subscribing to AAII's A+ Investor provides access to comprehensive analytics and insights for confident investing.